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NJBMS - Volume 9 Issue 2, October - December 2018

Pages: 65-70
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Fasting Plasma Lactate and Type 2 Diabetes Mellitus A Cross-Sectional Study

Author: N.E.Nandhini, D.Ponnudhali, Evangeline Jones

Category: Biochemistry

Abstract:

Introduction: Plasma lactate, a clinical marker of ischemic status, have been related to insulin resistance, type 2 diabetes mellitus and obesity. Elevated fasting plasma lactate levels could be an independent risk factor for type 2 Diabetes mellitus.

Aims and Objectives:

1) To assess the plasma lactate levels in type 2 diabetic patients and healthy controls.

2) To evaluate the correlation of plasma lactate with fasting blood glucose and HbA1c.

3) To evaluate the correlation between plasma lactate and lipid parameters

Materials and Methods: It is a cross- sectional study, conducted in 60 subjects, divided into 2 groups. Group A-30 normal healthy controls. Group B- 30 diabetic patients. Plasma lactate , FBS, HbA1c and lipid parameters were assessed in all 3 groups. All the above parameters were compared between the groups using independent student 't' test and Pearson's correlations were obtained between lactate and other parameters, using SPSS 23 software.

Results: Fasting plasma lactate levels were significantly elevated in type 2 diabetes mellitus patients when compared to controls (p=0.000) and had a positive association with fasting blood glucose & HbA1C levels in type 2 Diabetes mellitus patients.

Conclusion: The elevated lactate levels is related to the occurence of diabetes mellitus and reduced oxidative capacity could be the linking factor between hyperlactatemia and insulin resistance.If hyperlactatemia is an early change in altered glucose homeostasis, it could be a good predictor of future occurrence of type 2 diabetes mellitus.

Keywords: Plasma lactate, oxidative capacity, hyperlactemia, insulin resistance.

DOI: 10.31975/NJBMS.2018.9201

DOI URL: http://dx.doi.org/10.31975/NJBMS.2018.9201