Join us   Log in  

NJBMS - Volume 9 Issue 4, April - June 2019

Pages: 147-153
Print Article   Download XML  Download PDF

Evaluation of Serum Uric Acid and Metabolic Risk Factors in Type 2 Diabetes Mellitus

Author: Dr. C.K.Vijayasamundeeswari, Dr. R. Sudha

Category: Biochemistry


Background: Diabetes and Hypertension have emerged as a major public health issue worldwide and important risk factors for cardiovascular disease resulting in increased morbidity and mortality. Considering the strong association between the levels of serum uric acid (SUA) and the occurence of cardiovascular disease in subjects with type 2 diabetes mellitus (Type 2 DM), it is important to know whether importance should be laid on early screening of blood uric acid levels. This would help in early diagnosis, prevention, and treatment of complications of hypertension and diabetes mellitus.

Aims and objectives:

1. To compare the levels of serum uric acid in type 2 diabetes mellitus with and without hypertension.

2. To determine the association between serum uric acid levels and blood pressure, blood glucose in Type 2 Diabetes mellitus patients.

Materials and Methods : A cross sectional study was carried out in 120 patients with type 2 diabetes mellitus and 60 healthy controls. They were further divided into three groups. Group I includes 60 healthy subjects. Group II includes 60 type 2 diabetes mellitus patients without Hypertension and Group III includes 60 type 2 diabetes mellitus patients with Hypertension.

Results: The blood levels of uric acid, glucose, triglycerides and BMI were found to be increased significantly in the diabetic group compared to those in the controls where as HDL was significantly decreased in diabetic group compared to controls. A positive correlation was observed for the serum uric acid levels with plasma fasting glucose [r =

.320], postprandial blood glucose [r = .396], systolic [r = .526], and diastolic blood pressure [r = .400] in type 2 diabetes mellitus patients .

Conclusion: The present study concludes that the serum uric acid levels in hypertensive diabetics are significantly increased when compared to non-hypertensive diabetics.

Keywords: Serum uric acid, Type 2 diabetes mellitus, Hypertension

DOI: 10.31975/NJBMS.2019.9401