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NJBMS - Volume 2, Issue 3, January - March 2012

Pages: 189-193
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Author: K. Malleshappa, P. Rajasekhar, L. Jayalakshmi

Category: Physiology


Objective : To evaluate the association between Homocysteine, Ischemia modified albumin(IMA),lipids & inflammation biomarkers in apparently healthy obese young adults & the possible involvement of IMA in atheromatous plaque development & oxidative stress

Materials & methods : This was a cross-sectional study done on 138 apparently healthy obese young adults aged between 20-30yrs.Homocysteine,IMA,total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, oxidized LDL(ox-LDL),ox-LDL autoantibodies, high sensitivity C Reactive Protein(hs-CRP) were measured. The study subjects were divided into 2 groups based on total cholesterol levels, one group with high cholesterol level & the other with normal cholesterol level

Results : Hyperhomocysteinemia was found in 56 hypercholesterolemia subjects(69%) & in 32 subjects with normal cholesterol level(57%) & hyperhomo- cysteinemia was associated with altered lipid profile. total cholesterol, LDL cholesterol, triglycerides, ox-LDL, ox-LDL autoantibodies, hs-CRP & IMA were higher in the hypercholesterolemia group, & HDL cholesterol levels were lower in this group. We observed significant correlations between IMA & total cholesterol, LDL cholesterol, ox-LDL antibodies, & hs-CRP levels. there was also significant correlations between hs-CRP & total cholesterol, HDL cholesterol, LDL cholesterol, ox-LDL, ox- LDL autoantibodies, & triglycerides

Conclusion : The study focuses on the association seen, between hyperhomocysteinemia & altered lipid profile & also the association of hypercholesterolemia with an increase in inflammatory & oxidative stress biomarkers,among apparently healthy obese young adults. Hence interventional strategies are urgently needed among obese young adults for prevention of cardiovascular diseases

Keywords: Homocysteine, Ischemia modified albumin, inflammation, oxidative stress, obese young adults