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NJBMS - Volume 2, Issue 3, January - March 2012

Pages: 194-198
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Author: LingutlaSwethaBindu, Kalavathi.L

Category: Physiology


Introduction: In view of several potential sources of variability for lung functions like gender, age, body size, race, ethnicity, instrumentation, technique etc. an attempt is made to investigate the changes in forced vital capacity (FVC), forced expiratory volume in one second(FEV1), FEV1/FVC ratio, midexpiratory flow rate (FEF25-75%)and peak expiratory flow rate (PEFR) in healthy males correlated to age , height and weight using a computerized spirometer..

Aims : To study the relation of age, height and weight with FVC, FEV1, FEV1/FVC, FEF 25-75% and PEFR in males.

Material and Methods: A cross sectional study of computerized lung functions was undertaken between march and october 2009 in a medical College. 40 healthy males were drawn after screening through a questionnaire from the campus and stratified into 4 age groups of 10 members each - G1; 20-29 years, G2; 30-39 years, G3; 40-49 years and G4; 50-59 years. Standing height and weight were measured. Using a computerized spirometer ,FVC, FEV1, FEV1/FVC, FEF 25-75% and PEFR were measured. The data was analysed by ANOVA, Correlation matrix, linear regression analysis. Regression coefficients were tested for significance and null hypothesis.

Results : The bivariate correlation analysis showed that age was the strongest predictive factor for FEV1/FVC and FEF (25-75%) whereas height for FVC, FEV1 , FEV1/FVC and PEFR . Linear regression and multiple linear regression for age and height, developed very well for FEV1/FVC and FEF 25-75%.

Conclusion : FEV1/FVC and FEF 25-75% are more predictively influenced by age and height than FVC, FEV1 and PEFR .

Keywords: : Age, Height, Weight, FEV1/FVC and FEF (25- 75%)