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NJBMS - Volume 10 Issue 3, January - March 2020

Pages: 77-84
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Study On Biochemical Analysis Of Factors Involved In The Pathogenesis Of Uterine Fibroid Disorder

Author: C.K.Vijayasamundeeswari, V. Shanmugapriya, D. Karthikeyan

Category: Biochemistry


Introduction: Uterine fibroids are the commonest smooth muscle tumours that originate from the uterus. Several factors are involved in the pathogenesis like the reproductive hormones, age, family history, parity and race.

Aims and objectives: To analyze the biochemical parameters in fibroid cases and to compare the same with healthy study subjects.

Materials and methods: 45 uterine fibroid cases and 45 age matched controls were studied for their biochemical parameters lipid profile, liver function tests, complete blood count and blood grouping & typing.

Results& Discussion: Patients with uterine fibroids had earlier age of menarche and first child when compared to normal subjects. They were anemic with low hemoglobin count Hb (gm %) 8.6 ± 2.12 against controls 10.8 ± 3.1. Their HDL (mg/dl) was low with mean value 40.4 ± 5.9 compared to control values (50.9±6.8). In liver function tests, alkaline phosphatase(IU/L) was significantly elevated 190.8 ± 32.8 IU/L when compared to the controls with mean value of 110.5 ±24.5 IU/L. Interestingly most of patients were found to have blood group B positive (62.22%).

Conclusion: Uterine fibroids are more common in the reproductive age group especially in women between 30-50 years of age. Most of the patients with fibroid are found to have blood group B type with Rh positive.

Keywords: Uterine fibroids, Lipid profile, Alkaline phosphatase, Blood grouping

DOI: 10.31975/NJBMS.2020.10031