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<PublisherName>njbms</PublisherName>
<JournalTitle>NJBMS</JournalTitle>
<PISSN>0976-6626</PISSN>
<EISSN>2455-1740</EISSN>
<Volume-Issue>volume 10 issue 4</Volume-Issue>
<PartNumber/>
<IssueTopic>Multidisciplinary</IssueTopic>
<IssueLanguage>English</IssueLanguage>
<Season>April - June 2020</Season>
<SpecialIssue>N</SpecialIssue>
<SupplementaryIssue>N</SupplementaryIssue>
<IssueOA>Y</IssueOA>
<PubDate>
<Year>2020</Year>
<Month>05</Month>
<Day>26</Day>
</PubDate>
<ArticleType>Biochemistry</ArticleType>
<ArticleTitle>Is Oligonephronia an origin of renal disease?</ArticleTitle>
<SubTitle/>
<ArticleLanguage>English</ArticleLanguage>
<ArticleOA>Y</ArticleOA>
<FirstPage>10</FirstPage>
<LastPage>15</LastPage>
<AuthorList>
<Author>
<FirstName>Jones</FirstName>
<LastName>Ronald</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>N</CorrespondingAuthor>
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<DOI>//dx.doi.org/10.31975/NJBMS.2020.10401</DOI>
<Abstract>We have been all taught over the years that each kidney has approximately one million nephrons. It has been found now that there is a lot of variation in nephron number between individuals. Epidemiological research now supports the hypothesis proposed two decades ago by Brenner et al, that a low nephron count at birth may result in hypertension (HTN) and chronic kidney disease (CKD) in later life. It has been found that low birth weight is a strong surrogate marker associated with low nephron numbers. Other clinical associations of low nephron numbers have been listed as female gender, short stature, smaller kidneys and most importantly, prematurity. Caucasians and Australian Aborigines have found to have low nephron number and is associated with increased incidence of high blood pressure in them. On histological examination, glomerular volume is found to be inversely proportional to the nephron number indicating compensatory hypertrophy with the triggering factor being low nephron number. This can lead to progressive decline in renal function precipitated by subsequent insults in later life. It has been now found that in infants born with low nephron number, prevalence of hypertension and chronic kidney disease are high. If the causes that lead to this low nephron number at birth could be identified and treated during the antenatal period, by a good antenatal care, it may help in reducing the global burden of hypertension and renal disease.</Abstract>
<AbstractLanguage>English</AbstractLanguage>
<Keywords>Low Nephron Number,Low Birth Weight,Chronic kidney disease,Oligonephronia</Keywords>
<URLs>
<Abstract>https://njbms.in/ubijournal-v1copy/journals/abstract.php?article_id=13038&title=Is Oligonephronia an origin of renal disease?</Abstract>
</URLs>
<References>
<ReferencesarticleTitle>References</ReferencesarticleTitle>
<ReferencesfirstPage>16</ReferencesfirstPage>
<ReferenceslastPage>19</ReferenceslastPage>
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