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    <Journal>
      <PublisherName>njbms</PublisherName>
      <JournalTitle>NJBMS</JournalTitle>
      <PISSN>0976-6626</PISSN>
      <EISSN>2455-1740</EISSN>
      <Volume-Issue>Volume 11, Issue 2</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>October - December 2020</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>2020</Year>
        <Month>10</Month>
        <Day>6</Day>
      </PubDate>
      <ArticleType>Microbiology</ArticleType>
      <ArticleTitle>DETECTION OF COLISTIN RESISTANCE AMONG CARBAPENEM RESISTANT GRAM NEGATIVE BACILLI IN SEPTICAEMIC PATIENTS AT A TERITARY CARE HOSPITAL</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>191</FirstPage>
      <LastPage>195</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Dr. A.</FirstName>
          <LastName>Sowmya</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Dr. C.</FirstName>
          <LastName>Silambarasi</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Dr. R. Indra</FirstName>
          <LastName>Priyadharsini</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Dr. S.</FirstName>
          <LastName>Mathavi</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>Introduction: Colistin belongs to the family of Polymyxins, cationic polypeptides, with broad-spectrum activity against Gram-negative bacteria. In spite of their toxicity, Polymyxins have important therapeutic options in many hospitals. Carbapenem-resistance occurs in Enterobacteriaceae due to the enzyme carbapenemase produced by them. Most of the Carbapenem resistant gram negative bacteria are found to be resistant to Colistin as well. The colistin resistance in Gram-negative bacteria is because of modifications of lipid A by addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and/or phosphoethanolamine (PEtn) to reduce the net LPS negative charge (affinity). Aim __ampersandsign Objectives: To isolate carbapenem resistant Gram Negative Bacilli (GNB) from blood samples collected from septicemic patients and to detect Colistin resistance among them. Materials and Methods: This cross sectional prospective study was conducted for a period of 2 years from July 2015 to May 2017.1108 blood samples were collected from hospitalized patients with septicaemia and Carbapenem resistance was detected by disk diffusion method. The isolates that showed the zone size of less than 19mm to Imipenem were considered to be resistant and were tested for Colistin resistance. Colistin resistance was determined by MIC as per Standard Guidelines. Result: Out of 1108 blood samples, 106 gram negative bacilli were isolated. In that, 22 isolates were Carbapenem resistant and 4 isolates were Colistin resistant of which 1 (25%) was Klebsiella species, 2 [50%] Pseudomonas species and 1 [25%] Acinetobacter species.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Colistin resistance, Septicaemia, Carbapenemase, Gram negative bacilli, Modified Hodge Test, Microbroth dilution method</Keywords>
      <URLs>
        <Abstract>https://njbms.in/ubijournal-v1copy/journals/abstract.php?article_id=13255&amp;title=DETECTION OF COLISTIN RESISTANCE AMONG CARBAPENEM RESISTANT GRAM NEGATIVE BACILLI IN SEPTICAEMIC PATIENTS AT A TERITARY CARE HOSPITAL</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
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