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<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
      <Volume-Issue>Volume 1, Issue 4</Volume-Issue>
      <Season>April - June 2011</Season>
          <FirstName>VANISHREE B. J</FirstName>
          <FirstName>M. V. KODLIWADMATH</FirstName>
          <FirstName>C. V. B. PRASAD</FirstName>
          <FirstName>SMITA S.</FirstName>
      <Abstract>BackgroundMyocardial infarction (MI) is the single largest killer disease in the world. Oxidative stress is one of the hallmarks in patients with acute myocardial infarction as observed in recent years.Aim and ObjectivesThe objective of the study was to evaluate oxidative stress and antioxidant enzyme activity in patients of acute MI.Material and methodsThe present study comprised of 50 clinically diagnosed and ECG confirmed cases of acute MI and 50 healthy controls. Oxidative stress marker malondialdehyde (MDA) and enzymatic antioxidants like superoxide dismutase (SOD), catalase and glutathione Reductase were estimated in the cases and controls. Statistical analysis was carried out by using students't' test (unpaired). Correlation analysiswasdone by using SPSS software version 16. Result The MDA level was significantly increased (P&lt; 0.0001) in the cases (11.5 ± 0.72 nmol/ml) as compared to controls (6.3 ± 0.92 nmol/ml). The activity of SOD, glutathione reductase and catalasewere significantly low (P&lt; 0.0001) in acuteMI (450.0 ± 116.76 IU/g Hb, 3.1 ± 0.79 IU/g of Hb and 2.6 ± 0.53 IU/g of Hb respectively) as compared to controls (940.4 ± 93.9 IU/g of Hb, 9 ± 1.02 IU/g of Hb and 7.3 ± 0.70 IU/g of Hb respectively). A significant negative correlation was detected between malondialdehyde and catalase activity in acute MI (r= - 0.339; p</Abstract>
      <Keywords>Acute myocardial i n farction,malondialdehyde, antioxidants, superoxide dismutase,catalase, glutathione reductase.</Keywords>
        <Abstract>https://njbms.in/ubijournal-v1copy/journals/abstract.php?article_id=1450&amp;title=OXIDATIVE STRESS AND ENZYMATIC ANTIOXIDANTS IN ACUTE MYOCARDIAL INFARCTION</Abstract>