<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
<ArticleSet>
  <Article>
    <Journal>
      <PublisherName>njbms</PublisherName>
      <JournalTitle>NJBMS</JournalTitle>
      <PISSN>0976-6626</PISSN>
      <EISSN>2455-1740</EISSN>
      <Volume-Issue>Volume 4, Issue 3</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>January - March 2014</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>Biochemistry</ArticleType>
      <ArticleTitle>ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM (G894T) IN ESSENTIAL HYPERTENSION</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>151</FirstPage>
      <LastPage>154</LastPage>
      <AuthorList>
        <Author>
          <FirstName>V.</FirstName>
          <LastName>RAJAGOPAL</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>D.</FirstName>
          <LastName>PONNUDHALI</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>RITA MARY</FirstName>
          <LastName>ARUNA</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>EVANGELINE</FirstName>
          <LastName>JONES</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>Background: Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) plays an important role in maintaining blood pressure homeostasis and vascular integrity. The single nucleotide polymorphism (G894T)  in exon 7 of human eNOS gene has been found to be associated with the development of essential hypertension in different ethnic populations. Aim  and Objectives: (a) The aim is to assess the G894T polymorphism of eNOS gene in patients with essential hypertension in a rural population of Salem, Tamil Nadu. (b) Also to determine the genotype and mutant allele (&lsquo;T&rsquo;) frequency in them. Materials and Methods: Polymerase chain reaction and restriction fragment analysis was done to detect the presence of (G894T) variant of the eNOS gene in 41 hypertensive patients. Results: The frequency of the eNOS GG, GT, and TT genotypes was found to be 88%, 12%, and 0% respectively. The frequency of mutant (T) allele was found to be only 6.1%. Conclusion: The occurrence of homozygous wild G/G genotype is predominant and the homozygous mutant T/T genotype was not seen in the representative hypertensive subjects of our population in Salem. The presence of mutant(T) allele among the studied population was less common.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords/>
      <URLs>
        <Abstract>https://njbms.in/ubijournal-v1copy/journals/abstract.php?article_id=1522&amp;title=ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM (G894T) IN ESSENTIAL HYPERTENSION</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References/>
      </References>
    </Journal>
  </Article>
</ArticleSet>