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  <Article>
    <Journal>
      <PublisherName>njbms</PublisherName>
      <JournalTitle>NJBMS</JournalTitle>
      <PISSN>0976-6626</PISSN>
      <EISSN>2455-1740</EISSN>
      <Volume-Issue>Volume 3, Issue 3</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>January - March 2013</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>Pathology</ArticleType>
      <ArticleTitle>HER-2/NEU OVEREXPRESSION IN GASTRIC ADENOCARCINOMA - AN EXPERIENCE AT TERTIARY CARE CENTRE</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>216</FirstPage>
      <LastPage>220</LastPage>
      <AuthorList>
        <Author>
          <FirstName>B.V.</FirstName>
          <LastName>MADHAVI</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>B. RAVI</FirstName>
          <LastName>SHANKAR</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>B. SRIDHAR</FirstName>
          <LastName>REDDY</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>CH.</FirstName>
          <LastName>BALAJI</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>A. BHAGYA</FirstName>
          <LastName>LAKSHMI</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>HER-2 / neu over expression in gastric adenocarcinoma is a negative prognostic factor, ranging in expression between 6-35%.The purpose of the study is to analyse the over ex pression of HER-2/neu i n G astric adenocarcinoma by IHC and confirmation by FISH. This is an analytical study from July 2008 to June 2010 in the department of pathology at a tertiary care centre. In forty two cases with diagnosis of gastric adenocarcinoma, HER -2/neu over expression was scored on IHC. Cases with HER-2/neu expression of 3+ and 2+ cases were subjected to FISH. Out of 42 cases, 36 cases showed negative HER- 2/neu expression. Two cases with IHC score of 3+ had shown amplification on FISH and 4 cases with 2+ score did not show any amplification. In the present study HER- 2/neu over expression was seen in 5% of gastric adenocarcinoma. All cases with IHC score 3+ showed HER-2/neu amplification on FISH.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Gastric adenocarcinoma, HER-2/neu, Immunohistochemistry (IHC), Fluorescence in situ Hybridization (FISH).</Keywords>
      <URLs>
        <Abstract>https://njbms.in/ubijournal-v1copy/journals/abstract.php?article_id=1648&amp;title=HER-2/NEU OVEREXPRESSION IN GASTRIC ADENOCARCINOMA - AN EXPERIENCE AT TERTIARY CARE CENTRE</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References/>
      </References>
    </Journal>
  </Article>
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