<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>njbms</PublisherName> <JournalTitle>NJBMS</JournalTitle> <PISSN>0976-6626</PISSN> <EISSN>2455-1740</EISSN> <Volume-Issue>Volume 3, Issue 3</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>January - March 2013</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>-0001</Year> <Month>11</Month> <Day>30</Day> </PubDate> <ArticleType>Pharmacology</ArticleType> <ArticleTitle>A RETROSPECTIVE STUDY OF PATTERN OF ANTIMICROBIAL PROPHYLAXIS AND SURGICAL SITE INFECTION IN ABDOMINAL SURGERIES IN A TERTIARY CARE HOSPITAL</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>221</FirstPage> <LastPage>226</LastPage> <AuthorList> <Author> <FirstName>BASAVARAJ</FirstName> <LastName>BHANDARE</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> <FirstName>SATYANARAYANA</FirstName> <LastName>.V</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>JYOTIRMOY</FirstName> <LastName>ADHIKARY</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI/> <Abstract>Background : SSI is the third most commonly reported nosocomial infection. Appropriate AMP has been found to be effective in reducing SSI , but inappropriate use is associated with increase in the cost and emergence of bacterial resistance.Aim: This study was aimed to determine the pattern of prophylactic antimicrobial utilization and incidence of SSI in abdominal surgeries .Settings and Design: This retrospective observational study included patients who had undergone abdominal surgeries in the Department of General Surgery and Obstetrics and Gyaenacology over a period 10 months.Material and methods : 500 abdominal surgeries were considered for study and data collected includes, types of surgeries ; wound classes ; choice, dose, route, timing and duration of AMP apart from demographic profile of the patients.Statistical Analysis: Chi-square test was applied at 5% level of significance.Results : In our study overall SSI rate was 12.4 %. Two drug combination of Cefotaxim and Metronidazole was most commonly used antibiotic ( 49.2 %). A significant statistical correlation was found between timing of AMP and SSI rate (P < 0.05 , χ2 = 5.5). But no statistically significant correlation was found between duration of AMP and SSI (P > 0.05 , χ2 = 0.1182 ).Conclusion : As inappropriate use of antimicrobials is a significant factor for development of bacterial resistance, therefore judicious use of prophylactic antimicrobials with respect to choice, dose, route, time and duration is very essential</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>Surgical site infection (SSI), Antimicrobial prophylaxis (AMP), Abdominal surgery.</Keywords> <URLs> <Abstract>https://njbms.in/ubijournal-v1copy/journals/abstract.php?article_id=1649&title=A RETROSPECTIVE STUDY OF PATTERN OF ANTIMICROBIAL PROPHYLAXIS AND SURGICAL SITE INFECTION IN ABDOMINAL SURGERIES IN A TERTIARY CARE HOSPITAL</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References/> </References> </Journal> </Article> </ArticleSet>