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  <Article>
    <Journal>
      <PublisherName>njbms</PublisherName>
      <JournalTitle>NJBMS</JournalTitle>
      <PISSN>0976-6626</PISSN>
      <EISSN>2455-1740</EISSN>
      <Volume-Issue>Volume 7, Issue 3</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>January - March 2017</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>Biochemistry</ArticleType>
      <ArticleTitle>Association of Plasma Cholesteryl Ester Transfer Protein Activity with Severity of Angiographically Confirmed Coronary Artery Disease</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>145</FirstPage>
      <LastPage>152</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Umamaheswari.V</FirstName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Veena</FirstName>
          <LastName>Juliette.A</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Renuka.P</FirstName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>Background: Cholesteryl ester transfer protein (CETP), a hydrophobic glycoprotein has a key role in high- density lipoprotein cholesterol (HDL-C) metabolism. It transfers cholesteryl esters from HDL to apolipoprotein-B containing particles in exchange for triglycerides, thereby reducing the concentration of HDL-C and increasing non-HDL-C, a lipoprotein distribution predisposing to atheroma formation. Plasma CETPactivity has been associated with plasma HDL-C concentrations.Objectives: To determine the association of plasma CETP activity and its associated plasma lipoproteins concentration with angiographically confirmed Coronary artery disease (CAD).Materials and Methods: In this case-control study, we analysed the plasma CETP activity in 146 patients with angiographically proven Coronary atherosclerosis and 145 non-cardiac cases as control subjects. Plasma CETP activity was determined by fluorometry and serum lipoproteins wereestimated by routine enzymatic end point methods using an autoanalyser.Results: Patients with CAD had significantly high plasma CETP activity (90.72+15.83pmol/μL/hr) than control subjects (65.23 + 12.23pmol/μL/hr, P=0.000). CAD patients with single, double or triple vessel disease had significantly high CETP activity when compared to control subjects. Significantly lower HDL-C (38.5+9.7 mg/dl versus 48.2+9.9 mg/dL,P=0.000) was observed in Coronary atherosclerosis patients than control subjects.Conclusion: Our findings indicated that the plasma CETP activity was significantly associated with severity of Coronary artery disease and CETP activity may be an independent risk factor for Coronary atherosclerosis.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Cholesteryl ester transfer protein, High density lipoprotein,Coronary artery disease</Keywords>
      <URLs>
        <Abstract>https://njbms.in/ubijournal-v1copy/journals/abstract.php?article_id=2616&amp;title=Association of Plasma Cholesteryl Ester Transfer Protein Activity with Severity of Angiographically Confirmed Coronary Artery Disease</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References/>
      </References>
    </Journal>
  </Article>
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