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  <Article>
    <Journal>
      <PublisherName>njbms</PublisherName>
      <JournalTitle>NJBMS</JournalTitle>
      <PISSN>0976-6626</PISSN>
      <EISSN>2455-1740</EISSN>
      <Volume-Issue>Volume 2, Issue 1</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>July - September 2011</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>Pharmacology</ArticleType>
      <ArticleTitle>STUDY TO COMPARE THE CLINICAL EFFICACY OF ORAL THEOPHYLLINE, TIOTROPIUM BROMIDE AND COMBINATION OF FORMOTEROL AND BUDESONIDE IN COPD</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>38</FirstPage>
      <LastPage>42</LastPage>
      <AuthorList>
        <Author>
          <FirstName>KAVITHA RAJARATHNA</FirstName>
          <LastName/>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>SUSHMA M</FirstName>
          <LastName/>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>VIJAYA RAJENDRAN</FirstName>
          <LastName/>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>MURALI MOHAN</FirstName>
          <LastName>BV</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>COPD is a progressive disease that is fully not reversible. Drugs are used to prevent exacerbations, to improve the quality of life and slow the progression of the disease. In this randomized double-blinded/ double-dummy, parallel group comparative study involving 60 subjects (of whom 46 completed the trial), a comparison of efficacy (FVC) was made between the most commonly used drugs, theophylline, inhaled tiotropium (DPI), and a combination of formoterol-budesonide by inhaler (DPI). Tiotropium bromide improved FVC significantly. Theophylline also improved the lung function, but was associated with the highest drop-out rate probably due to adverse effects. The formoterol-budesonide combination did not provide statistically significant improvements in FVC. Though the individual drugs did help, it was the combination of all the three drugs that best improved the FVC.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>COPD, theophylline, inhaled tiotropium (DPI), formoterol-budesonide</Keywords>
      <URLs>
        <Abstract>https://njbms.in/ubijournal-v1copy/journals/abstract.php?article_id=3281&amp;title=STUDY TO COMPARE THE CLINICAL EFFICACY OF ORAL THEOPHYLLINE, TIOTROPIUM BROMIDE AND COMBINATION OF FORMOTEROL AND BUDESONIDE IN COPD</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References/>
      </References>
    </Journal>
  </Article>
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