SERUM LIPIDS AND APOPROTEIN B LEVELS IN NEONATES AND THEIR CORRELATION WITH MATERNAL LIPID PROFILE & PLACENTAL WEIGHT

Author: Dr. PUSHPENDRA MAGON , Dr. REBECCA ABRAHAM , Dr. MANORAMA VERMA , Dr. JUGESH CHATWAL

Category: Biochemistry

Abstract:

To establish correlation if any between neonatal lipid profile and Apoprotein B levels and maternal nutritional markers (lipids, Apo-B and placental weight). Correlation of lipid profile of newborns with markers of maternal nutrition. Settings: Department of Pediatrics, Department of Obstetrics & Gynecology. New born babies and their mothers. Methods: The cord blood samples at birth and peripheral blood samples at oneweek of agewere taken from500 neonates and their mothers and tested for lipid parameters viz. cholesterol, LDL, HDL, VLDL, Chylomicrons, LDL-C, HDL-C, and VLDL-C. The weight of mother's placentawas also taken upto the nearest 10 grams. The mean maternal lipid values and Apo-B levels were significantly higher compared to their newborns. No significant correlation could be made between maternal lipids and neonatal plasma lipids except that infant's HDLC approached closest to maternal HDLC levels. Amongst the "preterms", babies born to mothers with acceptable cholesterol levels (less than 240 mg/dl) had favorable lipid profile compared to those born to mothers with unacceptably high cholesterol levels (more than 240 mg/dl). No such difference was seen amongst the term new borns. It was also noted that as the placental weight increases, the cholesterol, LDL (low density lipoprotein) and Apo-B (Apoprotein B) rise correspondingly. This correlation was maintained even at one week of age. The strength of correlation between placentalweight and mean lipid values highlights the importance of such a study, where placental weight and maternal lipid values have been taken as markers ofmaternal nutrition.

Keywords: Maternal nutrition, Placentalweight, lipid profile, Cholesterol, LDL, Apo-B