Date of Publication: 30-Nov--0001
SERUM CERULOPLASMIN ALBUMIN RATIO AS A BIOCHEMICAL MARKER TO ASSIST THE DIAGNOSIS AND PROGNOSIS OF PULMONARY TUBERCULOSIS PATIENTS
Author: A.ARSHIYA BEGUM, K. NIRMALADEVI, P. DEEPALAKSHMI, B. SARAVANAN
Background: Pulmonary tuberculosis (PTB) is the most prevalent communicable disease worldwide, caused by Mycobacterium TB. Inflammatory response is mediated by acute phase reactants of which ceruloplasmin is a positive phase reactant and albumin, a negative phase reactant.
Aim: To estimate and to compare the serum level of cerulo- plasmin, albumin (C/A) and its ratio in newly diagnosed TB patients, patients on treatment, cured patients, and normal healthy individuals. To determine its role in the diagnosis and prognosis of the PTB patients.
Settings and Design: A cross-sectional study was conducted at TB hospital attached to KAPV Medical College, Tiruchirappalli, over a period of 3-month.
Materials and Methods: 100 individuals which includes 75 TB patients with sputum-positive pulmonary tuberculosis and 25 healthy controls were taken for the study and divided into 4 groups. Group 1 - newly diagnosed patients, Group 2 - patients on treatment, Group 3 - cured patients, and Group 4 - normal healthy individuals. Serum ceruloplasmin was estimated by RAVINS method. Serum albumin was measured by BCG method. Statistical analy- sis was done by SPSS-16 software.
Results: Mean value of C/A ratio in Groups 1-4 were 21 ± 7.69, 19 ± 4.4, 3.2 ± 0.38, and 4.3 ± 0.52, respectively. C/A ratio is significantly increased (P < 0.01) in newly diagnosed TB patients when compared to normal individuals. The C/A ratio in cured patients is significantly decreased when compared to newly diagnosed patients (P < 0.01).
Conclusion: In spite of recent advances and newer techniques, biochemical parameters which include C/A ratio can be used as a marker to assist in the diagnosis and prognosis of the disease.
Keywords: Acute phase reactant, Albumin, Ceruloplasmin, Tuberculosis