Serum Ceruloplasmin Levels in Acute Myocardial Infarction

Author: Vinayak Rengan. S, Meera. V, Komala. G

Category: Biochemistry

Abstract:

Introduction: Cardio-vascular diseases are the most common cause of death in India from the age of 25 to 69 years. Atherosclerosis seems to be a chronic inflammatory condition that is converted to an acute clinical event by the induction of plaque rupture. Ceruloplasmin is an inflammation sensitive as well as an acute phase protein. The purpose of the study is to determine the efficacy of ceruloplasmin as a diagnostic tool in Acute Myocardial Infarction (AMI). Its efficacy is also tested and compared with (high sensitivity C-Reactive protein) hs-CRP whose diagnostic potential is also assesed.

Aim& Objective: To evaluate the role of serum ceruloplasmin levels in Acute Myocardial Infarction.

Materials and Methods: Age matched 107 persons were enlisted in the study out of which 51 were AMI patients and 56 were controls. Routine blood investigations were carried out along with serum Ceruloplasmin and hs-CRP.

Results: The cases and controls were age matched. Levels of Ceruloplasmin was significantly high in the present study suggests that Acute Myocardial Infarction is an inflammatory event. Blood glucose and urea levels in the cases were found to be significantly higher than the controls. But there was no significant difference in creatinine levels between cases and controls. This study has showed that ceruloplasmin is a more sensitive and specific indicator of Myocardial Infarction than C- Reactive Protein.

Conclusion: The present study concludes that Serum Ceruloplasmin levels are a better indicator of Myocardial Infarction than C-Reactive Protein due to better specificity and sensitivity at a diagnostic cutoff of 60mg/dl is proved.

Keywords: Ceruloplasmin, C-reactive protein, Myocardial Infarction, Inflammation and Oxidative stress