National Journal of Basic Medical Sciences


Pages: 10-15

Date of Publication: 30-Nov--0001

Association of Serum Uric Acid with Nutritional Risk Index in Maintenance Hemodialysis Patients

Author: Sivasangari.S, Sudha.R, Jones Ronald, Evangeline Jones

Category: Biochemistry

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Background: Nutritional status assessment is important in detection of protein energy malnutrition in Chronic Kidney Disease (CKD) patients on Maintenance Hemodialysis (MHD). Nutritional Risk Index can be used as a screening tool for assessment of nutritional status with high sensitivity.

Aims and objectives:

• To assess the serum uric acid levels and nutritional risk index in maintenance hemodialysis patients

• To correlate serum uric acid and NRI in MHD patients.

Materials and Methods: A Cross sectional study was done in 50 End Stage Renal Disease (ESRD) patients undergoing therapeutic hemodialysis. Anthropometric measurements were noted and all the patients were analyzed for serum urea, creatinine, uric acid and albumin. NRI was calculated by NRI = (1.519 × serum albumin (g/L) + 41.7× (present weight/usual weight).

Results: The mean values of uric acid and albumin in MHD patients were 5.15± 1.15 mg/dl and 3.39± 0.40 g/dl respectively. Mean NRI score was 96.54± 3.89. 54% of patients had moderate risk, 8% had mild risk and 39% had no risk of malnutrition. Serum uric acid had a significant positive correlation with albumin (r= 0.39) and NRI (r= 0.68), (p value < 0.001). Serum uric acid positively associates with albumin and nutritional status in MHD patients. So, assessment of malnutrition and correction at an earlier stage can be done by using simple markers like serum uric acid.

Conclusion: Serum Uric acid levels are significantly associated with Nutritional parameters in MHD patients and can be used as a marker of Nutritional status in them.

Keywords: Uric Acid, Maintenance Hemodialysis, Protein energy malnutrition, Nutritional Riskindex.