Date of Publication: 30-Nov--0001
Histopathological Study of Endometrium in Abnormal Uterine Bleeding - An Experience in a Tertiary Care Centre of Rural South India
Author: Puvitha.R.D., Elavarasan.T., Shruthi.M.S., Shylaja.S.
Introduction: Abnormal uterine bleeding continues to be one of the most frequently encountered complaints in Gynecology and one of the most common and perplexing problems both to the patient and the gynecologist. It is defined as a pattern of bleeding that does not correspond with the duration, amount and frequency of the flow of a normal menstrual cycle.
Aim and Objectives: The present study was carried out to document the histomorphological pattern of endometrium in abnormal uterine bleeding, to correlate it with age and symptoms and the incidence of malignancy in this subset of population.
Material and methods: This is a retrospective study done on the patients with chief complaints of AUB and infertility in the Department of pathology, Govt. Dharmapuri Medical College, Dharmapuri, for a period of two years, includes 228 cases, in the age group of 21-65 years, who subjected for endometrial biopsies. The biopsies obtained, were sent in 10% neutral buffered formalin, underwent the routine processing, stained and studied under light microscopy.
Results: Clustering of cases were around 41-50 years representing 48.7%, with metro menorrhagia as chief complaints in 29%. The commonest pathology observed is Disordered Proliferative endometrium in 71 Patients (31.1%) and proliferative endometrium in 25.9%. In perimenopausal age group, Hyperplasia with atypia was frequently noted, with very low incidence of malignancy in this subset of population.
Conclusion: Histopathological examination of endometrial biopsy is an important tool to diagnose, whether benign, pre-malignant and malignant, and help the gynecologist to decide appropriate therapeutic strategy. Hence, the reporting pathologist should be vigilant, as it has an impact on patient's life and treatment.
Keywords: Abnormal uterine bleeding, Endometrium, Infertility, Disordered proliferative endometrium